This is one of the most emotionally trying influences. It is frequently associated with domestic or professional problems, emotional depression, loneliness, difficulties with women or difficulties with personal relationships, often leading to breakups.
This influence represents an "alienation crisis," that is, a crisis brought about by the discovery that you have been neglecting your emotional and psychological needs. As a result you feel alone and disconnected from others, like an alien in the world whom no one else can ever adequately understand.
To a greater or lesser extent, everyone's life revolves around an overall task or purpose that makes one's life unique. The purpose may be a job, motherhood, fatherhood, some movement that you believe in or anything else that gives you a sense of purpose. Often an alienation crisis occurs when you discover that you have gone too far too fast in pursuit of your life purpose and have neglected your psychological and emotional needs. Perhaps you have neglected your relationships or your domestic life, or you have repressed your feelings. In this way you build up a wall between yourself and others, which makes you feel alone and alienated.
You must make your personal life and your profession or other central purpose work together. That will require changing your lifestyle so that you can pay equal attention to both.